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Boosting lateral flow immunoassay sensitivity by increasing antigen-antibody interaction time and test line antibody concentrationArticleLateral flow immunoassays (LFIAs) are useful tools for point of care diagnostic testing. Improving their sensitivity can help prevent the spread of viruses like SARS-CoV-2 by detecting infections earlier. In effort of lowering the limit of detection of their COVID-19 rapid antigen test, scientists at Hilab have developed a rapid test prototype called “lateral flow intermembrane immunoassay test” that brings the limit of detection to 2.0 ng/mL of SARS-CoV-2 nucleocapsid protein1.
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Antibody-based sensors for multiplex point-of-care drug monitoringArticleTo improve point-of-care drug detection, scientists developed a multiplex drug monitoring sensor that uses antibodies to bind amphetamine, cocaine, or benzodiazepine1. The binding of these drugs reduces the oxidation current in a concentration dependent manner where higher concentrations of the drug cause a greater decrease in oxidation current. The sensor is selective for these drugs as interferences from analgesics and other illicit drugs had minimal effects on the current change.
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Control Line Systems for Lateral Flow AssaysArticleLateral flow tests consist of a test line and a control line. The control line provides validation of a functioning test. If the control line does not appear after running the test, that test is deemed invalid. The choice of a control line antibody will depend on which detector antibody is used in the test.
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Lateral Flow Assay Tests for Detecting Drugs of AbuseArticleDrug molecules are small and if directly striped on a membrane, they would “sink” into the sponge-like matrix of the nitrocellulose membrane. Consequently, drug molecules are conjugated to a carrier protein such as Bovine Serum Albumin (BSA) (most common), Bovine thyroglobulin (BTG), and even ovalbumin. The carrier protein part of the conjugate binds to the membrane and exposes the drug for the antibodies to “find”. In most drug tests, the drug BSA conjugate will be on the capture or test line and the antibody to that drug or its metabolites is bound to a detector particle such as gold nanoparticles or colored latex beads.
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Drugs of Abuse Pairing GuideEbookAt Fortis Life Sciences®, we understand the importance of accurate and reliable rapid diagnostic tests for detecting drugs of abuse. That's why we are a global supplier of matched pairs of drug test reagents for use in lateral flow formats. Accelerate your development timeline by referencing this pairing guide for the selection of compatible drug test reagents.